Indoxole an indole derivative is effective against carrageenin-induced edema in intact and adrenalectomized rats and in mice and gerbils. In the present study, an attempt was made to investigate anti-inflammatory activity of I3C (indole-3-carbinol) analogue and its metal complexes. Indeed, the paradox that copper can play both anti-inflammatory and pro-oxidant roles is related to the nature of the biological molecules bound to the metal in vivo. The copper, vanadium and zinc complex were formed with I3C (indole-3-carbinol) ligand. Effect on carrageenan induced mice paw edema, Acetic acid induced writhing, COX-2 inhibition in vitro models were performed to study the anti-inflammatory activity. To summarize the anti-inflammatory activity of I3C analogue and its metal complexes it was observed that copper complex showed highest activity in reduction of edema in carrageenan induced paw edema, protection against acetic acid induced writhing and COX-2 inhibition in vitro followed by zinc, vanadium complexes than plain I3C ligand.
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